Shortening a trailing vine
Trace one vine from its tip before choosing a cut.

What to look for
For a branching vine such as pothos, follow the stem you want to shorten. Find a healthy leaf node on the part that will remain, and separate nearby vines so you can see the connection clearly.
What to do
Cut that stem just above the chosen node with clean shears, keeping nearby leaves and stems intact. Begin with one vine; do not cut into a node or remove roots just to make the plant look tidy.